Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

The Formation and Function of Granulomas.

Pagán, Antonio J; Ramakrishnan, Lalita.

Annu Rev Immunol ; 36: 639-665, 2018 04 26.

Artigo em Inglês | MEDLINE | ID: mdl-29400999

2.

mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity.

Pagán, Antonio J; Lee, Lauren J; Edwards-Hicks, Joy; Moens, Cecilia B; Tobin, David M; Busch-Nentwich, Elisabeth M; Pearce, Erika L; Ramakrishnan, Lalita.

Cell ; 185(20): 3720-3738.e13, 2022 09 29.

Artigo em Inglês | MEDLINE | ID: mdl-36103894

3.

SLeuthing Tuberculous Cough.

Behr, Marcel A; Edelstein, Paul H; Ramakrishnan, Lalita.

Cell ; 181(2): 230-232, 2020 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-32302566

4.

TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit.

Roca, Francisco J; Whitworth, Laura J; Redmond, Sarah; Jones, Ana A; Ramakrishnan, Lalita.

Cell ; 178(6): 1344-1361.e11, 2019 09 05.

Artigo em Inglês | MEDLINE | ID: mdl-31474371

5.

A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.

Madigan, Cressida A; Cambier, C J; Kelly-Scumpia, Kindra M; Scumpia, Philip O; Cheng, Tan-Yun; Zailaa, Joseph; Bloom, Barry R; Moody, D Branch; Smale, Stephen T; Sagasti, Alvaro; Modlin, Robert L; Ramakrishnan, Lalita.

Cell ; 170(5): 973-985.e10, 2017 Aug 24.

Artigo em Inglês | MEDLINE | ID: mdl-28841420

6.

Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration.

Berg, Russell D; Levitte, Steven; O'Sullivan, Mary P; O'Leary, Seónadh M; Cambier, C J; Cameron, James; Takaki, Kevin K; Moens, Cecilia B; Tobin, David M; Keane, Joseph; Ramakrishnan, Lalita.

Cell ; 165(1): 139-152, 2016 Mar 24.

Artigo em Inglês | MEDLINE | ID: mdl-27015311

7.

Host evasion and exploitation schemes of Mycobacterium tuberculosis.

Cambier, C J; Falkow, Stanley; Ramakrishnan, Lalita.

Cell ; 159(7): 1497-509, 2014 Dec 18.

Artigo em Inglês | MEDLINE | ID: mdl-25525872

8.

TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species.

Roca, Francisco J; Ramakrishnan, Lalita.

Cell ; 153(3): 521-34, 2013 Apr 25.

Artigo em Inglês | MEDLINE | ID: mdl-23582643

9.

Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections.

Tobin, David M; Roca, Francisco J; Oh, Sungwhan F; McFarland, Ross; Vickery, Thad W; Ray, John P; Ko, Dennis C; Zou, Yuxia; Bang, Nguyen D; Chau, Tran T H; Vary, Jay C; Hawn, Thomas R; Dunstan, Sarah J; Farrar, Jeremy J; Thwaites, Guy E; King, Mary-Claire; Serhan, Charles N; Ramakrishnan, Lalita.

Cell ; 148(3): 434-46, 2012 Feb 03.

Artigo em Inglês | MEDLINE | ID: mdl-22304914

10.

Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages.

Cambier, C J; O'Leary, Seónadh M; O'Sullivan, Mary P; Keane, Joseph; Ramakrishnan, Lalita.

Immunity ; 47(3): 552-565.e4, 2017 09 19.

Artigo em Inglês | MEDLINE | ID: mdl-28844797

11.

Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism.

Adams, Kristin N; Takaki, Kevin; Connolly, Lynn E; Wiedenhoft, Heather; Winglee, Kathryn; Humbert, Olivier; Edelstein, Paul H; Cosma, Christine L; Ramakrishnan, Lalita.

Cell ; 145(1): 39-53, 2011 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-21376383

12.

Gaucher disease protects against tuberculosis.

Fan, Jingwen; Hale, Victoria L; Lelieveld, Lindsey T; Whitworth, Laura J; Busch-Nentwich, Elisabeth M; Troll, Mark; Edelstein, Paul H; Cox, Timothy M; Roca, Francisco J; Aerts, Johannes M F G; Ramakrishnan, Lalita.

Proc Natl Acad Sci U S A ; 120(7): e2217673120, 2023 02 14.

Artigo em Inglês | MEDLINE | ID: mdl-36745788

13.

The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance.

Lake, M Alexandra; Adams, Kristin N; Nie, Feilin; Fowler, Elaine; Verma, Amit K; Dei, Silvia; Teodori, Elisabetta; Sherman, David R; Edelstein, Paul H; Spring, David R; Troll, Mark; Ramakrishnan, Lalita.

Proc Natl Acad Sci U S A ; 120(7): e2215512120, 2023 02 14.

Artigo em Inglês | MEDLINE | ID: mdl-36763530

14.

The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans.

Tobin, David M; Vary, Jay C; Ray, John P; Walsh, Gregory S; Dunstan, Sarah J; Bang, Nguyen D; Hagge, Deanna A; Khadge, Saraswoti; King, Mary-Claire; Hawn, Thomas R; Moens, Cecilia B; Ramakrishnan, Lalita.

Cell ; 140(5): 717-30, 2010 Mar 05.

Artigo em Inglês | MEDLINE | ID: mdl-20211140

15.

The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence.

Osman, Morwan M; Shanahan, Jonathan K; Chu, Frances; Takaki, Kevin K; Pinckert, Malte L; Pagán, Antonio J; Brosch, Roland; Conrad, William H; Ramakrishnan, Lalita.

Proc Natl Acad Sci U S A ; 119(11): e2122161119, 2022 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-35271388

16.

TORmented macrophages spontaneously form granulomas.

Pagán, Antonio J; Ramakrishnan, Lalita.

Nat Immunol ; 18(3): 252-253, 2017 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-28198828

17.

The role of the granuloma in expansion and dissemination of early tuberculous infection.

Davis, J Muse; Ramakrishnan, Lalita.

Cell ; 136(1): 37-49, 2009 Jan 09.

Artigo em Inglês | MEDLINE | ID: mdl-19135887

18.

Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone.

Whitworth, Laura J; Troll, Rajan; Pagán, Antonio J; Roca, Francisco J; Edelstein, Paul H; Troll, Mark; Tobin, David M; Phu, Nguyen Hoan; Bang, Nguyen Duc; Thwaites, Guy E; Thuong, Nguyen Thuy Thuong; Sewell, Roger F; Ramakrishnan, Lalita.

Proc Natl Acad Sci U S A ; 118(10)2021 03 09.

Artigo em Inglês | MEDLINE | ID: mdl-33658385

19.

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids.

Cambier, C J; Takaki, Kevin K; Larson, Ryan P; Hernandez, Rafael E; Tobin, David M; Urdahl, Kevin B; Cosma, Christine L; Ramakrishnan, Lalita.

Nature ; 505(7482): 218-22, 2014 Jan 09.

Artigo em Inglês | MEDLINE | ID: mdl-24336213

20.

Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions.

Conrad, William H; Osman, Morwan M; Shanahan, Jonathan K; Chu, Frances; Takaki, Kevin K; Cameron, James; Hopkinson-Woolley, Digby; Brosch, Roland; Ramakrishnan, Lalita.

Proc Natl Acad Sci U S A ; 114(6): 1371-1376, 2017 02 07.

Artigo em Inglês | MEDLINE | ID: mdl-28119503

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